A cohort of 2,657 infants in Rochester, New York, who were given x-ray treatment for a purported enlarged thymus gland, along with 4,833 siblings, have been followed by mail surveys through about 1986, which represents an average of 37 years of followup, to determine their incidence of thyroid cancer.
Estimated thyroid doses ranged from 0.03 to >10 Gy, with 62% receiving <0.5 Gy.
There were 37 pathologically diagnosed thyroid cancers in the irradiated group and five in the sibling controls.
The dose-response relation was essentially linear, with no evidence of an additional dose-squared component.
The estimated relative risk at 1 Gy was 10 (90% confidence interval 5-23).
Mots-clés Pascal : Tumeur maligne, Epidémiologie, Irradiation RX, Thyroide, Thyroide pathologie, Toxicité retardée, Nourrisson, Homme, Rayonnement ionisant, Hypertrophie, New York, Etats Unis, Amérique du Nord, Amérique, Pharmacocinétique, Thymus, Etude cohorte, Etude longitudinale, Relation dose réponse
Mots-clés Pascal anglais : Malignant tumor, Epidemiology, X ray irradiation, Thyroid gland, Thyroid diseases, Delayed toxicity, Infant, Human, Ionizing radiation, Hypertrophy, New York, United States, North America, America, Pharmacokinetics, Thymus gland, Cohort study, Follow up study, Dose activity relation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0538181
Code Inist : 002B21C03. Création : 199406.