In many developing countries, the immunogenicity of three doses of live, attenuated, oral poliovirus vaccine (OPV) is lower than that in industrialised countries.
We evaluated serum neutralising antibody responses in 368 children aged 6 months and 346 children aged 9 months in Cote d'Ivoire who had previously received three doses of OPV at 2, 3, and 4 months of age, and who were then randomised to receive a supplemental dose of OPV or enhanced-potency inactivated poliovirus vaccine (IPV) at the time of measles vacci nation.
Although both vaccines increased seroconversion to all three poliovirus types, antibody responses were greater in the IPV group.
Mots-clés Pascal : Résultat, Traitement, Enfant, Homme, Etude comparative, Vaccination, Voie orale, Poliomyélite antérieure, Virose, Infection, Souche inactivée, Poliovirus, Enterovirus, Picornaviridae, Virus, Côte d'Ivoire, Afrique
Mots-clés Pascal anglais : Result, Treatment, Child, Human, Comparative study, Vaccination, Oral administration, Acute anterior poliomyelitis, Viral disease, Infection, Inactivated strain, Poliovirus, Enterovirus, Picornaviridae, Virus, Ivory Coast, Africa
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0531867
Code Inist : 002B02A02. Création : 199406.