Description of a computer model of forest onchocerciasis transmission and its application to field scenarios of vector control and chemotherapy.
This paper describes a computer simulation model for onchocerciasis (SIMON).
Using epidemiological and entomological data from a specific hyperendemic village in the forest area of Sierra Leone, the model is used to examine the effect of vector and chemotherapeutic controI strategies, both separately and in combination, as well as the risk to an uninfected population caused by immigrant, infected Simulium damnosum and humans.
The model suggests that, in this village, the human population of about 420 requires an average annual input of about 200 mature fecund, female Onchocerca volvulus per year to maintain a skin-snip prevalence of just under 70%. SIMON also predicts that 99% effective vector control would lead to eradication of all adult worms in 18 years, and that abandoning control before 14 years could lead to recrudescence.
Mots-clés Pascal : Onchocercose, Filariose, Nématodose, Helminthiase, Infection, Stratégie, Lutte sanitaire, Vecteur, Chimiothérapie, Simulation ordinateur, Transmission, Traitement
Mots-clés Pascal anglais : Onchocerciasis, Filariosis, Nematod disease, Helminthiasis, Infection, Strategy, Sanitary control, Vector, Chemotherapy, Computer simulation, Transmission, Treatment
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0525933
Code Inist : 002B05E03B4C. Création : 199406.