This study compared the epidemiology of Down syndrome over a 20-year period, 1970-1989, in two populations in which livebirths with Down syndrome were believed to be highly ascertained.
One population was a 10-county region in southwest Ohio; the second was a five-county region in metropolitan Atlanta, Georgia.
The major objectives were to 1) compare observed incidences of Down syndrome over the entire study period; 2) calculate expected incidences of Down syndrome for each population and compare these with observed incidences; 3) determine incidence trends throughout the period; and 4) examine the impact of prenatal diagnosis on the observed incidence of Down syndrome in each population.
Mots-clés Pascal : Trisomie, Aneuploïdie, Aberration chromosomique, Nourrisson, Homme, Etude comparative, Chromosome G21, Epidémiologie, Ohio, Etats Unis, Amérique du Nord, Amérique, Géorgie, Incidence, Race, Diagnostic, Prénatal
Mots-clés Pascal anglais : Trisomy, Aneuploidy, Chromosomal aberration, Infant, Human, Comparative study, G21-Chromosome, Epidemiology, Ohio, United States, North America, America, Georgia, Incidence, Race, Diagnosis, Prenatal
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0517051
Code Inist : 002B23B. Création : 199406.