Six healthy volunteers were exposed to gaseous hexahydrophthalic anhydride (HHPA) concentrations of 10, 40, or 80 mug.m-3 (65, 260 or 520 nmol.m-3, respectively) for 8 h. The respiratory uptake of the inhaled HHPA was almost complete.
Rapid increases in plasma and urinary levels of hexahydrophthalic acid (HHP acid) were seen.
During the first 4 h after the end of exposure, the half-time of HHP acid in plasma was about 2 h. A corresponding decay was seen in urine.
The correlations (r>0.90) between the air concentrations of HHPA and the levels of HHP acid in plasma and urine were close.
Mots-clés Pascal : Composé irritant, Homme, Inhalation, Toxicocinétique, Surveillance biologique, Sang, Urine, Excrétion, Médecine travail, Benzo[C]furane-1,3-dione(perhydro)
Mots-clés Pascal anglais : Irritant compound, Human, Inhalation, Toxicokinetics, Biological monitoring, Blood, Urine, Excretion, Occupational medicine
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0512185
Code Inist : 002B03L06. Création : 199406.