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  1. How sound is the double-blind design for evaluating psychotropic drugs ?

    Article - En anglais

    Sufficient data have accumulated to raise serious doubts about the integrity of the double-blind design that is presumed to shield psychotropic drug trials from bias and expectations.

    A major deficit in most drug trials has been the use of inert rather than active placebos.

    The deficiencies of the double-blind paradigm call for a questioning stance with respect to previous studies of psychotropic drug efficacy.

    Various possible ways of strengthening the double-blind paradigm are reviewed.

    Mots-clés Pascal : Psychotrope, Expérimentation, Etude critique, Etude double insu, Biais méthodologique, Méthodologie, Placebo, Essai clinique, Homme, Article synthèse

    Mots-clés Pascal anglais : Psychotropic, Experimentation, Critical study, Double blind study, Methodological bias, Methodology, Placebo, Clinical trial, Human, Review

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0503553

    Code Inist : 002B30A08. Création : 199406.