The authors present a method of estimating the duration of ongoing prevention trials, showing how the method was applied to the Colon Cancer Control Study, a University of Minnesota study of occult blood testing undertaken to screen for colorectal cancer in older Minnesotans.
In that study, begun in 1975 and ongoing, as in several other recent large prevention trials, it was necessary, after the start of the study, to revise upward the initial estimates of study duration derived from general population experience.
The underestimates arose because the planners had not adequately taken various population selection factors into account in estimating the expected number of events in the control group.
Mots-clés Pascal : Epidémiologie, Tumeur maligne, Appareil digestif pathologie, Minnesota, Etats Unis, Amérique du Nord, Amérique, Méthodologie, Biais méthodologique, Côlon, Rectum, Homme, Essai clinique, Mortalité, Prévention, Incidence, Echantillonnage
Mots-clés Pascal anglais : Epidemiology, Malignant tumor, Digestive diseases, Minnesota, United States, North America, America, Methodology, Methodological bias, Colon, Rectum, Human, Clinical trial, Mortality, Prevention, Incidence, Sampling
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0499725
Code Inist : 002B30A01A1. Création : 199406.