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  1. Treatment of childhood brucellosis : results of a prospective trial on 113 children.

    Article - En anglais

    Treatment of childhood brucellosis is controversial and is currently dependent on inclusion of aminoglycoside antibiotics which are both costly and potentially toxic.

    Hence an alternate mode of therapy preferably dependent exclusively on oral agents is desirable because this decreases medical cost.

    In this study we prospectively treated 113 children with a combination of two oral agents, trimethoprim-sulfamethoxazole (10 to 12 mg/kg trimethoprim, 50 to 60 mg/kg sulfamethoxazole and rifampin 15 to 20 mg/kg in two divided doses for 6 weeks.

    The treatment was well-tolerated and all patients responded by defervescence of fever and resolution of all symptoms within 1 to 3 weeks.

    Mots-clés Pascal : Brucellose, Bactériose, Infection, Triméthoprime, Sulfaméthoxazole, Chimiothérapie, Association médicamenteuse, Economie santé, Efficacité traitement, Toxicité, Rifampicine, Coût, Enfant, Homme, Antibiotique, Traitement, Voie orale, Antibactérien, Jordanie, Asie, Sulfamides

    Mots-clés Pascal anglais : Brucellosis, Bacteriosis, Infection, Chemotherapy, Drug combination, Health economy, Treatment efficiency, Toxicity, Costs, Child, Human, Antibiotic, Treatment, Oral administration, Antibacterial agent, Jordan, Asia, Sulfanilamide derivatives

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0487256

    Code Inist : 002B02S02. Création : 199406.