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  1. Economic assessment of maternal serum screening for Down's syndrome using human chorionic gonadotropin.

    Article - En anglais

    The effectiveness and costs of prenatal screening programmes for Down's syndrome using maternal serum markers will vary significantly depending on the biological cut-off values chosen in order to select women, at each maternal age, who will be sent for amniocentesis.

    On the basis of the first French prospective study of human chorionic gonadotropin (hCG) measurement in maternal serum, this paper shows that the screening protocol currently used in France, where hCG cut-off values are defined in order to offer amniocentesis to women of all ages with a 1 per cent fetal risk of Down's syndrome, would detect 64.06 per cent of all cases of trisomy 21 at birth and would be highly profitable for the French social security system.

    Mots-clés Pascal : Mongolisme, HCG, Trisomie, Aneuploïdie, Aberration chromosomique, Chromosome G21, Etude statistique, Gonadotrophine, Hormone placentaire, Diagnostic, Prénatal, Exploration hormonale, Marqueur biologique, Homme, Femelle, Gestation, France, Europe, Analyse avantage coût, Dépistage, Aspect économique

    Mots-clés Pascal anglais : Down syndrome, HCG, Trisomy, Aneuploidy, Chromosomal aberration, G21-Chromosome, Statistical study, Gonadotropin, Placental hormone, Diagnosis, Prenatal, Hormonal investigation, Biological marker, Human, Female, Pregnancy, France, Europe, Cost benefit analysis, Medical screening, Economic aspect

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0481551

    Code Inist : 002B20F03. Création : 199406.