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  1. The QUinapril ischemic event trial (QUIET) design and methods : evaluation of chronic ACE inhibitor therapy after coronary artery intervention.

    Article - En anglais

    The rationale, trial design, and statistical aspects of QUIET, the QUinapril Ischemic Event Trial, are described.

    QUIET is a prospective, double-blind placebo-controlled study that will assess the ability of the angiotensin-converting enzyme (ACE) inhibitor quinapril to reduce the rate of cardiac ischemic events and to slow or prevent the development of coronary artery atherosclerosis as assessed by serial angiography in a normolipidemic population without left ventricular dysfunction.

    The study began in September 1991 and has completed recruitment with 1740 patients across 38 centers (28 U.S., 4 Canada, 6 Europe) by the end of 1992.

    Patients are randomized to 20 mg of quinapril or placebo once daily and continue in the study for 3 year.

    Mots-clés Pascal : Quinapril, Inhibiteur enzyme, Angiotensin converting enzyme, Enzyme, Chimiothérapie, Ischémie, Myocarde, Athérosclérose, Traitement, Essai clinique, Angiographie, Homme, Vaisseau sanguin pathologie, Canada, Amérique du Nord, Amérique, Europe, Etats Unis, Cardiopathie coronaire, Appareil circulatoire pathologie

    Mots-clés Pascal anglais : Enzyme inhibitor, Angiotensin converting enzyme, Enzyme, Chemotherapy, Ischemia, Myocardium, Atherosclerosis, Treatment, Clinical trial, Angiography, Human, Vascular disease, Canada, North America, America, Europe, United States, Coronary heart disease, Cardiovascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0480528

    Code Inist : 002B02F03. Création : 199406.