Efficacy of hepatitis B vaccine in the Gambia expanded programme on immunisation.
Because of the high prevalence of hepatitis B virus (HBV) infection in The Gambia, HBV vaccination has been incorporated into the national expanded programme on immunisation.
We have assessed the efficacy of the vaccine against HBV infection and chronic carriage by examining 720 3-4-year-old children who had received the vaccine in infancy and 816 who had not received it.
The vaccine was 84% (95% Cl 78-89%) effective against infection and 94% (84-98%) effective against chronic carriage.
Vaccinated infants of mothers positive for hepatitis B surface and e antigens were at greater risk of breakthrough infection and chronic carriage than infants of uninfected mothers.
Mots-clés Pascal : Epidémiologie, Résultat, Homme, Vaccination, Hépatite virale B, Gambie, Afrique, Politique sanitaire
Mots-clés Pascal anglais : Epidemiology, Result, Human, Vaccination, Gambia, Africa, Health policy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0475953
Code Inist : 002B05A02. Création : 199406.