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  1. Vitamin A, infectious disease, and childhood mortality : a 2 solution ?

    Article - En anglais

    Vitamin A was first discovered in 1913.

    Its deficiency was soon associated in animal models and case reports with stunting, infection, and ocular changes (xerophthalmia) resulting in blindness.

    The ocular consequences dominated clinical interest through the early 1980s.

    A longitudinal prospective study of risk factors contributing to vitamin A deficiency and xerophthalmia revealed a close, dose-response relationship between the severity of mild preexisting vitamin A deficiency and the subsequent incidence of respiratory and diarrheal infection (relative risk (RR], 2.0-3.0) and, most dramatically, death (RR, 3.0-10.0).

    Subsequent community-based prophylaxis trials of varying design confirmed that vitamin A supplementation of deficient populations could reduce childhood (1-5 years old) mortality by an average of 35%.

    Mots-clés Pascal : Déficit, Infection, Rétinol, Symptomatologie, Métabolisme pathologie, Complication, Enfant, Homme, Facteur risque, Mortalité, Incidence, Prévention, Afrique, Carence vitaminique

    Mots-clés Pascal anglais : Deficiency, Infection, Retinol, Symptomatology, Metabolic diseases, Complication, Child, Human, Risk factor, Mortality, Incidence, Prevention, Africa, Vitamin deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0475132

    Code Inist : 002B22C. Création : 199406.