Vitamin A, infectious disease, and childhood mortality : a 2 solution ?
Vitamin A was first discovered in 1913.
Its deficiency was soon associated in animal models and case reports with stunting, infection, and ocular changes (xerophthalmia) resulting in blindness.
The ocular consequences dominated clinical interest through the early 1980s.
A longitudinal prospective study of risk factors contributing to vitamin A deficiency and xerophthalmia revealed a close, dose-response relationship between the severity of mild preexisting vitamin A deficiency and the subsequent incidence of respiratory and diarrheal infection (relative risk (RR], 2.0-3.0) and, most dramatically, death (RR, 3.0-10.0).
Subsequent community-based prophylaxis trials of varying design confirmed that vitamin A supplementation of deficient populations could reduce childhood (1-5 years old) mortality by an average of 35%.
Mots-clés Pascal : Déficit, Infection, Rétinol, Symptomatologie, Métabolisme pathologie, Complication, Enfant, Homme, Facteur risque, Mortalité, Incidence, Prévention, Afrique, Carence vitaminique
Mots-clés Pascal anglais : Deficiency, Infection, Retinol, Symptomatology, Metabolic diseases, Complication, Child, Human, Risk factor, Mortality, Incidence, Prevention, Africa, Vitamin deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0475132
Code Inist : 002B22C. Création : 199406.