Despite potential nephrotoxicity and ototoxicity, aminoglycosides are widely used in the treatment of severe sepsis but monitoring of serum levels is necessary.
The use and assay of aminoglycosides, together with microbiologists' and pharmacists' advice on dosage and potential toxicity were examined in a teaching hospital group during an eight week period.
A total of 480 courses of aminoglycoside was recorded in 440 hospital in-patients and of these, 306 (64%) were for prophylaxis.
For 79 (45%) of 174 therapeutic courses, bacteriological results were available at the start and the choice of antibiotic was appropriate in 69 cases.
Serum aminoglycoside assays were performed in 86% (149/174) of therapeutic courses.
Mots-clés Pascal : Prescription médicale, Royaume Uni, Europe, Milieu hospitalier, Néphropathie, ORL pathologie, Toxicité, Epidémiologie, Homme, Rein pathologie, Aminoglycoside, Antibiotique, Antibactérien, Appareil urinaire pathologie
Mots-clés Pascal anglais : Medical prescription, United Kingdom, Europe, Hospital environment, Nephropathy, ENT disease, Toxicity, Epidemiology, Human, Renal disease, Aminoglycoside, Antibiotic, Antibacterial agent, Urinary system disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0474544
Code Inist : 002B02U08. Création : 199406.