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  1. HTLV-I and HTLV-II world-wide distribution : reanalysis of 4,832 immunoblot results.

    Article - En anglais

    Mapping the geographic distribution of human T-lymphotrophic virus types 1 and 2 (HTLV-I and -II) has been complicated because conventional serologic approaches cannot distinguish between these 2 viruses.

    To more precisely define the epidemiology of HTLV-I and HTLV-II, we evaluated a convenience sample of 4,832 HTLV-I immunoblot results from over 140,000 samples screened for HTLV-I, collected in 16 countries for 35 separate studies.

    An algorithm that compares reactivity against p19 and p24, 2 gag (HTLV-I core) proteins, was employed to characterize the immunoblots: type 1, p19 stronger than p24 (presumptive HTLV-I), type 2, p24 stronger than p19 (presumptive HTLV-II), or indeterminate (p19 and p24 weakly positive or p19 weakly positive in the presence of p21e).

    Mots-clés Pascal : Virose, Infection, Répartition géographique, Diagnostic, Virus HTLV1, Retroviridae, Virus, Virus HTLV2, Monde, Epidémiologie, Méthode immunoblotting, Biologie moléculaire, Exploration, Homme

    Mots-clés Pascal anglais : Viral disease, Infection, Geographic distribution, Diagnosis, HTLV-I virus, Retroviridae, Virus, HTLV-II virus, World, Epidemiology, Immunoblotting assay, Molecular biology, Exploration, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0470225

    Code Inist : 002B19B. Création : 199406.