Human colorectal carcinoma tissue sampled from 37 patients, routinely graded into Dukes'stages A, B and C and histologically examined for the level of differentiation, were analyzed for the presence of point mutations in the K-ras oncogene.
Seventeen cases out of the 37 analyzed were found to have a mutation in either the 12th or the 13th codon of the K-ras gene, giving an overall frequency of mutation of 46%. The incidence of mutations in Dukes' stages A, B and C was 33, 46 and 58% respectively.
Although the frequency of mutation appears to be similar to that reported for the USA population, the spectrum of point mutations in codons 12 and 13 of the K-ras gene in the Yugoslav population appears to differ significantly.
Mots-clés Pascal : Epithélioma, Mutation ponctuelle, Epidémiologie, Côlon, Rectum, Tumeur maligne, Intestin pathologie, Gène onc cellulaire, Prévalence, Yougoslavie, Europe, Gène kras, Gène ras, Homme
Mots-clés Pascal anglais : Carcinoma, Point mutation, Epidemiology, Colon, Rectum, Malignant tumor, Intestinal disease, C-Onc gene, Prevalence, Yugoslavia, Europe, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0470224
Code Inist : 002B13B01. Création : 199406.