The joint effect of use of combination-type oral contraceptives and other exposure factors on risk of endometrial cancer was examined in data from a multicenter case-control study conducted in 5 areas of the United States.
Cases were 405 women with histologically confirmed invasive epithelial endometrial cancer first treated at one of 7 participating hospitals.
A total of 297 population-based controls of similar age, race, and geographic area were selected as a comparison group.
Information on exposure factors was derived from in-person interviews.
Combination-type oral contraceptive (COC) use was associated with a significant reduction in risk of endometrial cancer, with an adjusted odds ratio (OR) of 0.4 (95% confidence interval 0.3 to 0.7) for ever compared to never use.
Mots-clés Pascal : Tumeur maligne, Contraceptif, Endomètre, Facteur risque, Utérus pathologie, Appareil génital femelle pathologie, Voie orale, Epidémiologie, Homme
Mots-clés Pascal anglais : Malignant tumor, Contraceptive, Endometrium, Risk factor, Uterine diseases, Female genital diseases, Oral administration, Epidemiology, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0470223
Code Inist : 002B20C02. Création : 199406.