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  1. Autopsy : consent, completion and communication in Alzheimer's disease research.

    Article - En anglais

    The definitive diagnosis of Alzheimer's disease remains histopathological.

    To date many published studies have been limited by being based on clinical diagnosis alone, which has a significant false positive rate.

    In a prospective, longitudinal, clinicopathological study which aims to develop an antemortem diagnostic test for Alzheimer's disease, we have achieved 96% (2501260) consent and 97% (59161) completion rates.

    We here describe some of the factors we believe are responsible for these high rates and which may be relevant to other studies requiring autopsy to verify clinical diagnoses.

    Mots-clés Pascal : Démence Alzheimer, Maladie dégénérative, Système nerveux pathologie, Encéphale pathologie, Autopsie, Diagnostic, Consentement éclairé, Communication information, Recherche scientifique, Vieillard, Homme, Système nerveux central pathologie

    Mots-clés Pascal anglais : Alzheimer disease, Degenerative disease, Nervous system diseases, Cerebral disorder, Autopsy, Diagnosis, Informed consent, Information communication, Scientific research, Elderly, Human, Central nervous system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0467151

    Code Inist : 002B30A09. Création : 199406.