Predictive strategies for selecting 379 NCl/NTP chemicals evaluated for carcinogenic potential : scientific and public health impact.
The a priori criteria used by the National Cancer Institute/National Toxicology Program (NCI/NTP) are described for 379 chemicals selected and evaluated for carcinogenic potential.
We classified the chemicals according to exposure and structural categories and evaluated the predictive ability of the scientific selection criteria of chemicals suspected of being carcinogenic in advance of any study.
Of the 379 chemicals, 253 (67%) were selected with a suspicion of carcinogenicity; 171 (68%) of these 253 chemicals induced cancer in at least one of the sex-species experiments.
The other 126 (33%) chemicals were selected mainly, but not exclusively, on the basis of exposure considerations and production volumes; only 27 (21%) of these were judged to be positive.
Mots-clés Pascal : Composé chimique, Toxicité, Classification, Homme, Carcinogène, Test carcinogénicité, Prédiction, Programme recherche, Comparaison interspécifique, Animal, Relation structure activité
Mots-clés Pascal anglais : Chemical compound, Toxicity, Classification, Human, Carcinogen, Carcinogenicity testing, Prediction, Research program, Interspecific comparison, Animal, Structure activity relation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0463418
Code Inist : 002B04E02. Création : 199406.