To examine the relationship between HIV-1 infection of cells obtained by bronchoalveolar lavage (BAL) from the lung and the pathogenesis of AIDS.
Prospective study of 121 consecutive HIV-1-seropositive patients undergoing investigation for respiratory symptoms or abnormal chest radiograph.
Polymerase chain reaction (PCR) for the detection of HIV-1-specific proviral DNA.
Cocultivation of leukocytes obtained from BAL with donor cord blood leukocytes (CBL) to isolate HIV-1.
HIV-1 was detected by PCR in the lung cells of 78 out of 121 (65%) patients.
It was detected in 55% of patients who had been seropositive for less than 1 year, but in over 80% of patients who had been seropositive for more than 3 years.
Mots-clés Pascal : Immunodéficit acquis syndrome, Virose, Infection, Pneumonie, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Epidémiologie, Hémopathie, Immunopathologie, Maladie sexuellement transmissible, Pathogénie, Lavage bronchoalvéolaire, Appareil respiratoire pathologie, Homme, Poumon pathologie
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Pneumonia, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Epidemiology, Hemopathy, Immunopathology, Sexually transmitted disease, Pathogenesis, Bronchoalveolar lavage, Respiratory disease, Human, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0447315
Code Inist : 002B06D01. Création : 199406.