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  1. Cost-effective diagnosis of HIV-1 and HIV-2 by recombinant-expressed env peptide (566/996) dot-blot analysis.

    Article - En anglais


    To characterize the recombinant env peptides, 566 (HIV-1) and 996 (HIV-2), for their ability to serodiagnose HIV-1 and HIV-2 infection.

    To develop a cost-effective dot-blot format for these peptides, and to evaluate its performance in a developing country laboratory.


    The recombinant env peptides were evaluated using a select panel of sera (n=327) with known serostatus from geographically diverse areas.

    A dot-blot assay was developed and tested on a second set of immunoblotted sera (n=331) and further evaluated in the field on a third set of sera (n=2718) from study populations.

    Mots-clés Pascal : Immunodéficit acquis syndrome, Virose, Infection, Peptide, Diagnostic, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Virus HIV2, Hémopathie, Immunopathologie, Maladie sexuellement transmissible, Enveloppe virus, Sérologie, Analyse coût efficacité, Economie santé, Méthode blotting, Biologie moléculaire, Exploration, Afrique Ouest, Afrique, Homme

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Peptides, Diagnosis, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, HIV-2 virus, Hemopathy, Immunopathology, Sexually transmitted disease, Virus envelope, Serology, Cost efficiency analysis, Health economy, Blotting assay, Molecular biology, Exploration, West Africa, Africa, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0445988

    Code Inist : 002B06D01. Création : 199406.