The efficacy of a 12-mg/kg (of body weight) intramuscular amopyroquin (ApQ) regimen (two successive 6-mg/kg injections at a 24-h interval), previously established from kinetic studies on healthy volunteers and multicenter studies on patients with malaria, was investigated in 152 patients (children and adults) in Gabon with Plasmodium falciparum malaria.
All children in the present study (ages, 1 to 14 years) showed higher degrees of parasitemia and temperatures and lower hematocrit values than did adults at the time of admission.
No major side effects in the patients were observed.
On day 7, all patients were apyretic; clearance of parasites was obtained in 143 of 152 patients (94%); a low level of parasitemia was observed in nine patients, all of whom were children (6%).
Mots-clés Pascal : Amopyroquine, Antipaludique, Chimiothérapie, Traitement, Plasmodium falciparum, Sporozoa, Protozoa, Paludisme, Protozoose, Infection, Voie intramusculaire, Rythme administration, Epidémiologie, Adulte, Homme, Enfant, Gabon, Afrique
Mots-clés Pascal anglais : Antimalarial, Chemotherapy, Treatment, Plasmodium falciparum, Sporozoa, Protozoa, Malaria, Protozoal disease, Infection, Intramuscular administration, Administration schedule, Epidemiology, Adult, Human, Child, Gabon, Africa
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0444708
Code Inist : 002B02S06. Création : 199406.