To examine the prevalence of infection by human T-cell leukemia virus type I (HTLV-I) among seronegative subjects, healthy subjects on Tsushima Island, Japan, where the infection is endemic, were evaluated.
A total of 209 healthy adults were examined for HTLV-I provirus in peripheral blood mononuclear cells by the polymerase chain reaction (PCR), as well as for anti-HTLV-I antibodies by the particle agglutination (PA) method, the emyme-linked immunosorbent assay (ELISA) and by immunofluorescence analysis (IF).
A total of 76 subjects were positive and 133 were negative for the provirus, showing a close correlation with the results of 3 assays for anti-HTLV-I serum antibodies.
None of the seronegative subjects reacted positively on PCR analysis.
Mots-clés Pascal : Virose, Infection, Prévalence, Epidémiologie, Virus HTLV1, Retroviridae, Virus, Séronégativité, Endémie, Japon, Asie, Adulte, Homme, Ile Tsushima
Mots-clés Pascal anglais : Viral disease, Infection, Prevalence, Epidemiology, HTLV-I virus, Retroviridae, Virus, Seronegativity, Endemy, Japan, Asia, Adult, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0433445
Code Inist : 002B19B. Création : 199406.