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  1. Representative and misrepresentative associations of birth defects in livebirths : conditions under which relative risks greater than unity in livebirths necessarily imply relative risks greater than unity in all conceptuses.

    Article - En anglais

    One may express the relative risk of defect in all conceptuses, rdef, as a function of the relative risk of defect in livebirths, rdef,lb, and in embryonic and fetal deaths, rdef,efd, as rdef=clbrdef,lb+cefdrdef,efd, where clb and cefd are coefficients defined in terms of conceptus and defect viability and lethality.

    If the relative risk of birth defect in livebirths, rdef,lb, is greater than unity, but the relative risk of defect in all conceptuses, rdef, is equal to or less than unity (or the reverse pattern holds), then the relative risk of defects in livebirths may be said to be « distorting » or « misrepresentative » because it does not reflect the nature of the association in all conceptuses.

    Mots-clés Pascal : Malformation, Embryon, Nourrisson, Homme, Epidémiologie, Foetus, Analyse mathématique, Méthodologie, Biais méthodologique

    Mots-clés Pascal anglais : Malformation, Embryo, Infant, Human, Epidemiology, Fetus, Mathematical analysis, Methodology, Methodological bias

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0421705

    Code Inist : 002B30A01A. Création : 199406.