To evaluate the risk of childhood cancer among infants with serious birth defects, the authors linked records of the population-based registry of the Georgia Center for Cancer Statistics for 1975 to 1988 with records of the population-based Metropolitan Atlanta Congenital Defects Program for 1968 to 1987.
During the study period, birth defects were diagnosed in 19,373 infants younger than 1 year of age, and cancer was diagnosed in 400 children younger than 15 years of age.
The observed number of children with a defect who developed cancer was compared with the number expected on the basis of the cancer registry rates.
Of the 19,373 children with birth defects, 31 developed cancer (standardized incidence ratio (SIR)=2.2, 95% confidence interval (Cl) 1.5-3.2).
Mots-clés Pascal : Malformation, Tumeur maligne, Facteur risque, Trisomie, Aneuploïdie, Aberration chromosomique, Pylore, Nourrisson, Homme, Epidémiologie, Linkage, Dossier médical, Géorgie, Etats Unis, Amérique du Nord, Amérique, Chromosome G21, Sténose, Appareil digestif pathologie, Enfant
Mots-clés Pascal anglais : Malformation, Malignant tumor, Risk factor, Trisomy, Aneuploidy, Chromosomal aberration, Pylorus, Infant, Human, Epidemiology, Linkage, Medical record, Georgia, United States, North America, America, G21-Chromosome, Stenosis, Digestive diseases, Child
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0421701
Code Inist : 002B04B. Création : 199406.