The Risk of colo-rectal cancer (CRC) in subjects with a positive family history (FH+) for malignancy has been assessed by means of a case-control study carried out between 1987-89 in an area of about 215,000 inhabitants in Southern Italy.
One hundred and nineteen CRC cases were compared with 119 sex - and age frequency matched population controls.
Detailed pedigrees were collected at the family homes of both cases and controls.
The odds ratio (OR) of CRC, adjusted by means of logistic regression for age, sex and number of first-degree relatives, increased with the number of any kinds of cancers in first-degree relatives with a significant linear trend (p=0.042), while there was no risk with a FH+ for digestive cancer excluding CRC or for other cancers excluding large bowel and digestive organs.
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Héréditaire, Etude familiale, Histoire familiale, Homme, Epidémiologie, Facteur risque, Appareil digestif pathologie, Italie, Europe, Sud, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Hereditary, Family study, Family story, Human, Epidemiology, Risk factor, Digestive diseases, Italy, Europe, South, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0412247
Code Inist : 002B13B01. Création : 199406.