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  1. Analysis of Epstein-Barr virus infection in nasopharyngeal biopsies from a group at high risk of nasopharyngeal carcinoma.

    Article - En anglais

    Although Epstein-Barr virus (EBV) is consistently associated with the epithelial malignancy nasopharyngeal carcinoma (NPC), it is not clear to what extent the normal virus carrier state involves infection of nasopharyngeal epithelium.

    We attempted to examine this question by screening 26 nasopharyngeal punch biopsies from EBV-carrying Chinese Malaysians who had presented with clinical symptoms possibly indicative of NPC, but in whom histological analysis of an adjacent biopsy had revealed no evidence of tumour.

    Assays included (i) in situ hybridization with 35S-labelled riboprobes specific for EBERs.

    (rather than with BamHI W DNA probes which can give false-positive results).

    Mots-clés Pascal : Epithélioma, Virose, Infection, Chinois, Nasopharynx, Facteur risque, Tumeur maligne, ORL pathologie, Virus Epstein Barr, Gammaherpesvirinae, Herpesviridae, Virus, Biopsie, Malaisie, Asie, Epidémiologie, Homme, Nez pathologie, Pharynx pathologie

    Mots-clés Pascal anglais : Carcinoma, Viral disease, Infection, Chinese, Nasopharynx, Risk factor, Malignant tumor, ENT disease, Epstein Barr virus, Gammaherpesvirinae, Herpesviridae, Virus, Biopsy, Malaysia, Asia, Epidemiology, Human, Nasal disease, Pharyngeal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0410517

    Code Inist : 002B10B01. Création : 199406.