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  1. Rare Ha-ras1 alleles and predisposition to testicular cancer.

    Article - En anglais

    We have examined the restriction-fragment-length polymorphism (RFLP) of the VNTR region flanking the Ha-rasI gene in genomic DNA from 348 testicular cancer patients and 343 healthy controls.

    When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed 24 and 15 different alleles in the cancer and the control group respectively.

    The frequency of rare alleles among cases was significantly higher than in controls.

    Patients with bilateral cancer and patients with unilateral cancer below 20 years had significantly higher incidence of rare alleles than patients with unilateral cancer older than 20 years.

    Mots-clés Pascal : Tumeur maligne, Gène onc cellulaire, Epidémiologie, Testicule, Facteur risque, Testicule pathologie, Appareil génital mâle pathologie, Allèle, Déterminisme génétique, Norvège, Europe, Gène Ha ras1, Gène ras, Homme

    Mots-clés Pascal anglais : Malignant tumor, C-Onc gene, Epidemiology, Testicle, Risk factor, Testicular diseases, Male genital diseases, Allele, Inheritance, Norway, Europe, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0409284

    Code Inist : 002B20B02. Création : 199406.