Aspirin and other nonsteroidal antiinflammatorg drugs inhibit prostaglandin synthesis and tumor growth in many experimental systems, but it is unclear which of these tumor models are relevant to humans.
We have reported reduced risk of fatal colon cancer among persons who used aspirin in a large prospective study.
This analysis examines other fatal cancers in relation to aspirin among 635,031 adults in that study who provided information in 1982 on the frequency and duration of their aspirin use and did not report cancer.
Death rates were measured through 1988.
Death rates decreased with more frequent aspirin use for cancers of the esophagus, stomach, colon, and rectum but not generally for other cancers.
Mots-clés Pascal : Acétylsalicylique acide, Antiinflammatoire non stéroïde, Prévention, Traitement, Tumeur maligne, Côlon, Estomac, Appareil digestif pathologie, Homme, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Anticarcinogène
Mots-clés Pascal anglais : Non steroidal antiinflammatory agent, Prevention, Treatment, Malignant tumor, Colon, Stomach, Digestive diseases, Human, Epidemiology, United States, North America, America, Anticarcinogen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0396059
Code Inist : 002B13B01. Création : 199406.