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  1. The place of diuretics of the treatment of hypertension : a historical review of classical experience over 30 years.

    Article - En anglais

    Thiazide diuretics have been the mainstay of anti-hypertensive therapy for over 30 years.

    Their precise mechanism of antihypertensive action is still incompletely understood.

    They reduce arterial pressure initially through a fall in plasma volume and cardiac output.

    However, with chronic administration cardiac output tends to return towards pretreatment levels, suggesting that the long-term pressure reduction is mediated through a reduction in vascular resistance.

    Although multiple lines of evidence suggest that salt and water loss is an essential part of the mechanism, at least in some cases an indirect vasodilator effect may play a role as well.

    Mots-clés Pascal : Diurétique, Article synthèse, Chimiothérapie, Traitement, Homme, Historique, Epidémiologie, Thiazide, Hypertension artérielle, Appareil circulatoire pathologie, Hypokaliémie, Trouble métabolisme, Toxicité, Antihypertenseur

    Mots-clés Pascal anglais : Diuretic, Review, Chemotherapy, Treatment, Human, Case history, Epidemiology, Thiazide, Hypertension, Cardiovascular disease, Hypokaliemia, Metabolic disorder, Toxicity, Antihypertensive agent

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0383437

    Code Inist : 002B02F05. Création : 199406.