Fifty-eight clinical trials with negative conclusions, published in three British dermatological journals over the last 4 years, were reviewed to determine the risk of their having missed an effective treatment.
All but one of the 44 evaluable trials had a greater than 1 in 10 risk of missing a 25% relative treatment difference (median risk 81%), and 31 of the trials (70%) were so small that they had a greater than 1 in 10 risk of missing a 50% relative treatment difference (median risk 42%). The « negative » trial result was compatible (within 95% confidence limits) with a 25% beneficial relative treatment effect in 36 studies (82%), and a 50% treatment benefit in 22 studies (50%).
Mots-clés Pascal : Essai clinique, Résultat négatif, Dermatologie, Littérature scientifique, Méthodologie, Intervalle confiance, Erreur type II
Mots-clés Pascal anglais : Clinical trial, Negative result, Dermatology, Scientific literature, Methodology, Confidence interval
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0339468
Code Inist : 002B30A08. Création : 199406.