Meta-analysis of the literature or of individual patient data : is there a difference ?
The use of meta-analyses or overviews to combine formally the results of related randomised clinical trials is becoming increasingly common.
However the distinction between analyses based on information extracted from the published literature and those based on collecting and reanalysing updated individual patient data is not clear.
We have investigated the difference between meta-analysis of the literature (MAL) and meta - analysis of individual patient data (MAP) by comparing the two approaches using randomised trials of cisplatin-based therapy in ovarian cancer.
The MAL was based on 788 patients and the MAP on 1329 and estimated median follow-ups were 3.5 and 6.5 years, respectively.
Mots-clés Pascal : Homme, Etude comparative, Evaluation performance, Littérature scientifique, Individu, Donnée, Métaanalyse
Mots-clés Pascal anglais : Human, Comparative study, Performance evaluation, Scientific literature, Individual, Data, Metaanalysis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0334148
Code Inist : 002B30A11. Création : 199406.