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  1. Female hormone utilisation and risk of hepatocellular carcinoma.

    Article - En anglais

    The relationship between female hormone use and primary liver cancer was analysed using data from a case-control study conducted between 1984 and 1992 in Milan on 82 female incident cases with histologically or serologically confirmed hepatocellular carcinoma and 368 controls admitted to hospital for acute non-neoplastic, non-hormone-related diseases.

    An elevated relative risk (RR) or primary liver cancer was observed in oral contraceptive (OC) users (RR 2.6, for ever versus never users, 95% confidence interval, CI 1.0-7.0).

    The RR was directly related to duration of use (RR 1.5 for <=5 years and 3.9 for >5 years) and persisted for longer than 10 years after stopping use (RR 4.3%, 95% CI 1.0-18.2).

    Mots-clés Pascal : Hépatome, Oestrogène, Toxicité, Facteur risque, Contraception, Appareil digestif pathologie, Foie pathologie, Tumeur maligne, Epithélioma, Voie orale, Carcinogène, Italie, Europe, Epidémiologie, Homme

    Mots-clés Pascal anglais : Liver cell carcinoma, Estrogen, Toxicity, Risk factor, Contraception, Digestive diseases, Hepatic disease, Malignant tumor, Carcinoma, Oral administration, Carcinogen, Italy, Europe, Epidemiology, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0305010

    Code Inist : 002B02U08. Création : 199406.