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  1. K-ras mutations in human adenocarcinoma of the lung : association with smoking and occupational exposure to absestos.

    Article - En anglais

    We investigated point mutational activation of the ras genes (K-ras codons 12, 13 and 61; N-ras codons 12, 13 and 61; H-ras codons 12 and 61) in primary, resected lung cancer by dot blotting and oligonucleotide hybridization.

    K-ras mutations were found in 14 (29%) of the 48 lung tumour specimens examined, but no N-ras or H-ras mutations were found.

    The highest frequency of K-ras mutation was observed in adenocarcinoma: 12 of the 21 samples studied (57%) had a mutation, which is one of the highest frequencies reported for lung adenocarcinoma.

    Mots-clés Pascal : Epithélioma glandulaire, Gène onc cellulaire, Médecine travail, Bronchopulmonaire, Mutation ponctuelle, Tumeur maligne, Appareil respiratoire pathologie, Exposition professionnelle, Amiante, Tabagisme, Etiologie, Gène Kras, Gène ras, Homme, Poumon pathologie

    Mots-clés Pascal anglais : Adenocarcinoma, C-Onc gene, Occupational medicine, Bronchopulmonary, Point mutation, Malignant tumor, Respiratory disease, Occupational exposure, Asbestos, Tobacco smoking, Etiology, Human, Lung disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0278950

    Code Inist : 002B11A. Création : 199406.