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  1. The use of statistical methods in the analysis of clinical studies.

    Article - En anglais

    It is « standard » to analyze data from a clinical trial using a narrowly defined probabilistic mathematical model.

    This paper examines the ways in which mathematical models, in general, can be used in clinical research, the meaning of probability in the examination of clinical trials, and the philosophical flaws in the current « standard » method.

    An alternative formulation is proposed which is more flexible and which comes closer to meeting the needs of medical science.

    In this alternative formulation, significance tests are applied to the data from a study only as a first step to determine whether the data are worth further examination.

    Mots-clés Pascal : Essai clinique, Probabilité, Analyse statistique, Modèle mathématique, Méthodologie

    Mots-clés Pascal anglais : Clinical trial, Probability, Statistical analysis, Mathematical model, Methodology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0269394

    Code Inist : 002B30A01A1. Création : 199406.