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  1. Thalassemia in Southeast Asia: problems and strategy for prevention and control.

    Article - En anglais

    In Southeast Asia alpha-thalassemia, bêta-thalassemia, hemoglobin (Hb) E and Hb Constant Spring are prevalent.

    The gene frequencies of alpha-thalassemia reach 30-40% in Northern Thailand and Laos. bêta-Thalassemia gene frequencies vary between 1 and 9%. Hb E is the hallmark of Southeast Asia attaining a frequency of 50-60% at the junction of Thailand, Laos, and Cambodia.

    Hb Constant Spring gene frequencies vary between 1 and 8%. These abnormal genes in different combinations lead to over 60 different thalassemia syndromes.

    The four major thalassemic diseases are Hb Bart's hydrops fetalis (homozygous alpha-thalassemia 1), homozygous bêta-thalassemia, bêta-thalassemia/Hb E and Hb H diseases.

    Mots-clés Pascal : Thalassémie alpha, Thalassémie bêta, Asie du sud est, Asie, Epidémiologie, Stratégie, Prévention, Dépistage, Traitement, Programme sanitaire, Hémoglobinopathie, Hémopathie, Homme, Anémie hémolytique, Maladie héréditaire

    Mots-clés Pascal anglais : alpha-Thalassemia, bêta-Thalassemia, South east asia, Asia, Epidemiology, Strategy, Prevention, Medical screening, Treatment, Sanitary program, Hemoglobinopathy, Hemopathy, Human, Hemolytic anemia, Genetic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0454966

    Code Inist : 002B19A01. Création : 199406.