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  1. Quality-of-life assessment : can we keep it simple ?

    Article - En anglais

    The importance of general statistical principles of study design and analysis to quality-of-life assessment in clinical trials is emphasized.

    Basic methods are reviewed briefly, with reference to three examples.

    Careful use of standard tools supplemented with context-specific scales is recommended.

    Problems of weighting and aggregation are discussed; the use of simple weighting schemes supplemented by sensitivity analysis is suggested.

    Some technical issues are explored, including factorial question structure, components of variance to distinguish mean treatment and patient-specific treatment effects and informative loss to follow-up.

    Mots-clés Pascal : Qualité vie, Questionnaire, Validation test, Evaluation, Psychométrie, Méthode étude, Essai clinique, Fidélité test, Analyse statistique, Article synthèse

    Mots-clés Pascal anglais : Quality of life, Questionnaire, Test validation, Evaluation, Psychometrics, Investigation method, Clinical trial, Test reliability, Statistical analysis, Review

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0432226

    Code Inist : 002A26B02. Création : 199406.