Several birth defects surveillance systems have shown an upward trend in the birth prevalence of several congenital cardiovascular malformations.
Improvements in clinical ascertainment have been suggested as an explanation for this increase.
For several decades, 40-50% of infants with Down's syndrome have been reported to have cardiac defects associated with the unbalanced genotype.
Therefore, secular changes in the frequency of ascertained cardiovascular malformations among infants with Down's syndrome in surveillance systems could shed light on improvements in the ascertainment of these defects.
Mots-clés Pascal : Trisomie, Aneuploïdie, Aberration chromosomique, Cardiopathie, Nourrisson, Homme, Chromosome G21, Malformation, Appareil circulatoire pathologie, Coeur, Epidémiologie, Variation temporelle, Diagnostic, Géorgie, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Trisomy, Aneuploidy, Chromosomal aberration, Heart disease, Infant, Human, G21-Chromosome, Malformation, Cardiovascular disease, Heart, Epidemiology, Time variation, Diagnosis, Georgia, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0284058
Code Inist : 002B12A08. Création : 199406.