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  1. Improved ascertainment of cardiovascular malformations in infants with Down's syndrome, Atlanta, 1968 through 1989 : implications for the interpretation of increasing rates of cardiovascular malformations in surveillance systems.

    Article - En anglais

    Several birth defects surveillance systems have shown an upward trend in the birth prevalence of several congenital cardiovascular malformations.

    Improvements in clinical ascertainment have been suggested as an explanation for this increase.

    For several decades, 40-50% of infants with Down's syndrome have been reported to have cardiac defects associated with the unbalanced genotype.

    Therefore, secular changes in the frequency of ascertained cardiovascular malformations among infants with Down's syndrome in surveillance systems could shed light on improvements in the ascertainment of these defects.

    Mots-clés Pascal : Trisomie, Aneuploïdie, Aberration chromosomique, Cardiopathie, Nourrisson, Homme, Chromosome G21, Malformation, Appareil circulatoire pathologie, Coeur, Epidémiologie, Variation temporelle, Diagnostic, Géorgie, Etats Unis, Amérique du Nord, Amérique

    Mots-clés Pascal anglais : Trisomy, Aneuploidy, Chromosomal aberration, Heart disease, Infant, Human, G21-Chromosome, Malformation, Cardiovascular disease, Heart, Epidemiology, Time variation, Diagnosis, Georgia, United States, North America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0284058

    Code Inist : 002B12A08. Création : 199406.