Pregnancy estrogens are substantially elevated in twin pregnancies and are likely to be more so in the case of dizygotic twins.
If levels of pregnancy estrogens were positively related to breast cancer risk in the offspring, female twin members would be expected to be at slightly higher risk.
Data from an international case-control study were utilized to assess this hypothesis.
The analysis was based on 870 cases with breast cancer and 2,641 hospital controls from two sites:
Wales (1965-1967), and Boston,
Seventeen cases were members of twin pairs, and 8 of them had a twin brother; 33 controls were members of twin pairs and 14 had a twin brother.
Mots-clés Pascal : Tumeur maligne, Facteur risque, Multiple, Glande mammaire, Glande mammaire pathologie, Gestation, Oestrogène, Epidémiologie, Homme, Grossesse multiple, Jumeau, Pays de Galles, Grande Bretagne, Royaume Uni, Europe, Massachusetts, Etats Unis, Amérique du Nord, Amérique, Descendance, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Risk factor, Multiple, Mammary gland, Mammary gland diseases, Pregnancy, Estrogen, Epidemiology, Human, Twin, Wales, Great britain, United Kingdom, Europe, Massachusetts, United States, North America, America, Progeny, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0278999
Code Inist : 002B20E02. Création : 199406.