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  1. Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals.

    Article - En anglais

    The possibilities and limitations of using mercapturic acids and protein and DNA adducts for the assessment of internal and effective doses of electrophilic chemicals are reviewed.

    Electrophilic chemicals may be considered as potential mutagens and/or carcinogens.

    Mercapturic acids and protein and DNA adducts are considered as selective biomarkers because they reflect the chemical structure of the parent compounds or the reactive electrophilic metabolites formed during biotransformation.

    Mots-clés Pascal : Composé chimique, Electrophile, Toxicité, Mutagène, Carcinogène, Marqueur biologique, Adduit moléculaire, Surveillance biologique, Homme, Pesticide, Evaluation, Risque, Sulfure organique, Urine, Liquide biologique, Article synthèse, Cystéine(N-acétyl)

    Mots-clés Pascal anglais : Chemical compound, Electrophile, Toxicity, Mutagen, Carcinogen, Biological marker, Molecular adduct, Biological monitoring, Human, Pesticides, Evaluation, Risk, Organic sulfide, Urine, Biological fluid, Review

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0202910

    Code Inist : 002B03A. Création : 199406.