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  1. Beta-carotene supplementation in smokers reduces the frequency of micronuclei in sputum.

    Article - En anglais

    bêta-carotene has been hypothesised to reduce lung cancer risk.

    We studied the effect of 14 weeks of bêta-carotene supplementation (20 mg d-1) on the frequency of micronuclei insputum in 114 heavy smokers in a double-blind trial.

    Micronuclei reflect DNA damage in exfoliated cells and may thus provide a marker of early-stage carcinogenesis.

    Pre-treatment blood levels of cotinine, bêta-carotene, retinol and vitamins C and E were similar in the placebo group (n=61) and the treatment group (n=53).

    Plasma bêta-carotene levels increased 13-fold in the treatment group during intervention.

    Mots-clés Pascal : Tumeur maligne, Betacarotène, Micronucléus, Bronchopulmonaire, Facteur risque, Appareil respiratoire pathologie, Caroténoïde, Tabagisme, Anticancéreux, Expectoration, Prévention, Chimiothérapie, Traitement, Poumon pathologie, Epidémiologie, Homme

    Mots-clés Pascal anglais : Malignant tumor, Micronucleus, Bronchopulmonary, Risk factor, Respiratory disease, Carotenoid, Tobacco smoking, Antineoplastic agent, Sputum, Prevention, Chemotherapy, Treatment, Epidemiology, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0150229

    Code Inist : 002B02R02. Création : 199406.