DNA was extracted from the tumour tissue of 26 patients (18 smokers, 8 non-smokers) undergoing surgery for gastric cancer, and analyzed for the presence of DNA adducts by the 32P-post-labelling method.
Adducts were detected in all samples tested, and adduct levels ranged from 2 adducts/108 nucleotides to 60 adducts/108 nucleotides.
In male subjects, adduct levels were significantly greater in the DNA of smokers than in that of non-smokers.
These results support epidemiological data suggesting that smoking is a risk factor for gastric cancer.
Mots-clés Pascal : Tumeur maligne, Tabagisme, Epidémiologie, Estomac, Facteur risque, Estomac pathologie, Appareil digestif pathologie, DNA, Composé addition, Homme
Mots-clés Pascal anglais : Malignant tumor, Tobacco smoking, Epidemiology, Stomach, Risk factor, Gastric disease, Digestive diseases, DNA, Adduct, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 93-0145595
Code Inist : 002B13B01. Création : 199406.