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  1. Smoking-related DNA adducts in human gastric cancers.

    Article - En anglais

    DNA was extracted from the tumour tissue of 26 patients (18 smokers, 8 non-smokers) undergoing surgery for gastric cancer, and analyzed for the presence of DNA adducts by the 32P-post-labelling method.

    Adducts were detected in all samples tested, and adduct levels ranged from 2 adducts/108 nucleotides to 60 adducts/108 nucleotides.

    In male subjects, adduct levels were significantly greater in the DNA of smokers than in that of non-smokers.

    These results support epidemiological data suggesting that smoking is a risk factor for gastric cancer.

    Mots-clés Pascal : Tumeur maligne, Tabagisme, Epidémiologie, Estomac, Facteur risque, Estomac pathologie, Appareil digestif pathologie, DNA, Composé addition, Homme

    Mots-clés Pascal anglais : Malignant tumor, Tobacco smoking, Epidemiology, Stomach, Risk factor, Gastric disease, Digestive diseases, DNA, Adduct, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0145595

    Code Inist : 002B13B01. Création : 199406.