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  1. Large diurnal variation in CD4 cell count and T-cell function among drug users : implications for clinical practice and epidemiological studies.

    Article - En anglais

    Objective

    To measure diurnal variation in the CD4 cell count and T-cell reactivity of drug users.

    Design

    A prospective epidemiological study among HIV-infected and non-infected drug users attending the Municipal Health Service of Amsterdam, The Netherlands.

    Patients

    Eleven HIV-infected and seven non-infected drug users.

    Main outcome measures

    CD4 cell counts and T-cell reactivity three times a day.

    T-cell subsets and T-cell reactivity were determined from blinded samples within 2 hours.

    Results

    The number of CD4 cells increased by 130x106/l (p<0.05 in HIV-infected intravenous drug users over 8 hours.

    Mots-clés Pascal : Immunodéficit acquis syndrome, Virose, Infection, Lymphocyte T, Toxicomanie, Séropositivité, Fonction leucocytaire, Hémopathie, Immunopathologie, Sous population cellulaire, Variation diurne, Voie intraveineuse, Exploration immunologique, Antigène CD4, Epidémiologie, Pays Bas, Europe, Homme

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, T-Lymphocyte, Drug addiction, Seropositivity, Leukocyte function, Hemopathy, Immunopathology, Cell subpopulation, Diurnal variation, Intravenous administration, Immunological investigation, Epidemiology, Netherlands, Europe, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0110483

    Code Inist : 002B06D01. Création : 199406.