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  1. Controversial issues in 5-fluorouracil infusion use : dose intensity, treatment duration, and cost comparisons.

    Article, Congrès - En anglais

    National conference on new oncologic agents. Dallas TX (USA), 1991/02/06.


    The use of ambulatory infusions of S-fluorouracil (S-FU) improves the therapeutic index of this drug and is superior to the traditional schedule of bolus administration weekly or daily for 5 days at 5-week intervals.

    The infusion schedules that have been used vary as follows:

    • (1) 24-hour infusion weekly;

    • (2) 48-hour infusion weekly or biweekly;

    • (3) 120-hour infusion at 4-5-week intervals;

    • (4) 14-day infusion;

    • and (5) protracted infusions continuously for 10 weeks or more.

    The relationship of dose intensity to infusion duration and the analysis of costs of chemotherapy were reviewed.

    Mots-clés Pascal : Fluorouracil, Anticancéreux, Chimiothérapie, Pharmacologie, Traitement, Homme, Tumeur maligne, Voie intraveineuse, Technique, Relation dose réponse, Coût, Horaire, Rythme administration

    Mots-clés Pascal anglais : Antineoplastic agent, Chemotherapy, Pharmacology, Treatment, Human, Malignant tumor, Intravenous administration, Technique, Dose activity relation, Costs, Schedule, Administration schedule

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0073732

    Code Inist : 002B02R. Création : 199406.