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  1. Sample size calculations for the log rank test : a Gompertz model approach.

    Article - En anglais

    Sample size calculations for clinical trials dealing with survivorship are often based on an exponential model.

    This model is inappropriate when a non-zero proportion of the population is expected to have indefinite survival.

    In such cases the Gompertz model offers a reasonable alternative.

    A method for calculating the required accrual time for a clinical trial in which the treatment arms have Gompertz survival distributions satisfying the proportion hazards assumption is developed.

    Mots-clés Pascal : Essai clinique, Taille échantillon, Méthodologie, Echantillonnage, Modèle statistique, Survie, Modèle Gompertz

    Mots-clés Pascal anglais : Clinical trial, Sample size, Methodology, Sampling, Statistical model, Survival

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 93-0010303

    Code Inist : 002B30A08. Création : 199406.