Micronuclei in bronchial biopsy specimens from heavy smokers : characterization of an intermediate marker of lung carcinogenesis.
Bronchial micronuclei, small fragments of extra-nuclear DNA formed during cell division, provide a non-specific but quantifiable marker of DNA damage.
Micronuclei have been used to assess carcinogen exposure and as an intermediate endpoint in chemoprevention trials.
As part of an ongoing chemoprevention trial, heavy smokers underwent screening bronchoscopy, with biopsies taken at 6 standardized sites.
Micronuclei counts were obtained for each site in each of the 40 volunteers found to have squamous metaplasia.
Unlike squamous metaplasia, the average micronuclei counts among these heavy smokers were not associated with smoking history.
Mots-clés Pascal : Tumeur maligne, Tabagisme, Bronche, Bronchopulmonaire, Facteur risque, Appareil respiratoire pathologie, Marqueur biologique, Micronucléus, Homme, Biopsie, Anatomopathologie, Exploration
Mots-clés Pascal anglais : Malignant tumor, Tobacco smoking, Bronchus, Bronchopulmonary, Risk factor, Respiratory disease, Biological marker, Micronucleus, Human, Biopsy, Pathology, Exploration
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 92-0686534
Code Inist : 002B11A. Création : 199406.