In a retrospective cohort study, the mothers and sisters of 740 breast cancer patients aged under 36 at diagnosis have been studied for mortality and cancer incidence.
Significantly increased breast cancer mortality was observed below age 60 (30 deaths; SMR=3.4), but not at older ages (four deaths; SMR=0.9).
The cumulative breast cancer incidence in the relatives was 3.6% by age 50, 7.6% by age 60 and 11.6% by age 70.
They also suffered excess mortality below age 60 for cancers of reproductive sites (cervix, ovary and endometrium; 15 deaths; SMR=2.6) and lung (11 deaths; SMR=3.2), but not for other sites (12 deaths; SMR=0.9).
Mots-clés Pascal : Tumeur maligne, Etude cohorte, Glande mammaire, Mortalité, Glande mammaire pathologie, Adulte jeune, Homme, Apparenté premier degré
Mots-clés Pascal anglais : Malignant tumor, Cohort study, Mammary gland, Mortality, Mammary gland diseases, Young adult, Human, First degree relative
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 92-0650026
Code Inist : 002B20E02. Création : 199406.