Nine cases of de novo myelodysplastic syndromes (MDS) in childhood from a population based study are presented.
The annual incidence of MDS was 3.4/1 000 000 in children less than 15 years old, corresponding to 8.7% of all haematological malignancies in childhood.
Two patients had Down's syndrome.
None of the remaining patients had constitutional anomalies.
All patients were classified according to the FAB classification.
Five patients presented with refractory anaemia (RA), only one of these did not progress, one showed clonal evolution, and the remaining three patients all progressed to refractory anaemia with excess of blasts.
Mots-clés Pascal : Myélodysplasique syndrome, Danemark, Europe, Epidémiologie, Incidence, Etude cas, Hémopathie, Hémopathie maligne, Enfant, Homme
Mots-clés Pascal anglais : Myelodysplastic syndrome, Denmark, Europe, Epidemiology, Incidence, Case study, Hemopathy, Malignant hemopathy, Child, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 92-0606058
Code Inist : 002B19B. Création : 199406.