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  1. P53 mutations in human hepatocellular carcinomas from Germany.

    Article - En anglais

    Mutations in the p53 gene are frequent genetic alterations in human hepatocellular carcinomas.

    We have examined 13 cases of human hepatocellular carcinomas from Germany for the presence of p53 aberrations in exons 4 to 8 of the gene by single-strand conformation polymorphism and restriction fragment-length polymorphism analyses and by sequencing of polymerase chain reaction products.

    Single base substitutions occurred in two human hepatocellular carcinomas: a C:G-T:A transition at a CpG site in codon 257, and a T:A-A:T transversion at codon 273.

    Mots-clés Pascal : Pathogénie, Homme, Mutation, Polymorphisme longueur fragment restriction, Tumeur maligne, Appareil digestif pathologie, Foie, Hépatome, Exploration, Biologie moléculaire, Allemagne, Europe, Gène p53, Polymorphisme conformation simple brin, Gène suppresseur tumeur

    Mots-clés Pascal anglais : Pathogenesis, Human, Mutation, Restriction fragment length polymorphism, Malignant tumor, Digestive diseases, Liver, Liver cell carcinoma, Exploration, Molecular biology, Germany, Europe, Tumor suppressor gene

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 92-0546504

    Code Inist : 002B13C01. Création : 199406.