logo BDSP

Base documentaire

  1. Possible mechanisms of gastroduodenal mucosal damage in volunteers treated with nonsteroidal antiinflammatory drugs : the usefulness of prodrugs.

    Article - En anglais

    A controlled double blind study on the incidence of nonsteroidal antiinflammatory drug (NSAID) gastropathy was performed in 29 healthy volunteers administered diclofenac Na (10 subjects) or a prodrug (loxoprofen Na in 10 subjects and proglumetacin maleate in 9 subjects).

    The incidence of NSAID gastropathy was significantly lower in the subjects administered the prodrugs than in those administered diclofenac Na (p<0.05), which suggested the clinical usefulness of the prodrugs.

    Mots-clés Pascal : Chimiothérapie, Traitement, Antiinflammatoire non stéroïde, Toxicité, Appareil digestif pathologie, Gastrite, Estomac pathologie, Homme, Incidence, Epidémiologie, Diclofénac, Promédicament, Etude comparative, Loxoprofène, Proglumétacine

    Mots-clés Pascal anglais : Chemotherapy, Treatment, Non steroidal antiinflammatory agent, Toxicity, Digestive diseases, Gastritis, Gastric disease, Human, Incidence, Epidemiology, Prodrug, Comparative study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 92-0502755

    Code Inist : 002B02U04. Création : 199406.