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  1. Patterns of risk of hereditary retinoblastoma and applications to genetic counselling.

    Article - En anglais

    A registry including information about nearly 1,600 cases of retinoblastoma diagnosed in Britain has been created at the Childhood Cancer Research Group.

    Cases have been classified as « old germ cell mutation », « new germ cell mutation » or « sporadic non-hereditary ».

    For a population-based group of 918 cases diagnosed between 1962 and 1985 we have calculated the proportions of unilateral/bilateral and hereditary/non-hereditary cases.

    Bilateral cases represent 40% of the total number over this period; the proportion known to be hereditary is 44%, a higher proportion than has been reported elsewhere.

    Mots-clés Pascal : Rétinoblastome, Facteur risque, Fratrie, Descendance, Conseil génétique, Epidémiologie, Rétinopathie, Oeil pathologie, Maladie héréditaire, Tumeur maligne, Homme

    Mots-clés Pascal anglais : Retinoblastoma, Risk factor, Siblingship, Progeny, Genetic counseling, Epidemiology, Retinopathy, Eye disease, Genetic disease, Malignant tumor, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 92-0485178

    Code Inist : 002B09B. Création : 199406.